Protein Details: Inward rectifier potassium channel 16

Protein ID

ICDB_Pro_1580

Protein Name

Inward rectifier potassium channel 16

Gene Name

KCNJ16

Organism

Homo sapiens (Human)

Length

418 amino acids

AlphaFoldDB

AF-Q9NPI9-F1-model_v4.pdb

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney;together with KCNJ10;mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules

Sequence

MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVRESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Hypokalemic Tubulopathy And Deafness and Arrhythmogenic Right Ventricular Cardiomyopathy

Location

Widely expressed; with highest levels in adult and fetal kidney (at protein level). In the kidney; expressed in the proximal and distal convoluted tubules; but not in glomeruli nor collecting ducts.

DOI ID

10.1159/000015662; 10.1016/s0014-5793(01)02202-5; 10.1016/j.febslet.2014.02.024; 10.1681/asn.2020111587

RefSeq

NP_001257351.1; NP_001278551.1; NP_001278552.1; NP_001278553.1; NP_001278554.1; NP_061128.2; NP_733937.2; NP_733938.2; XP_011523083.1; XP_016880102.1